Post-extraction application of beta-tricalcium phosphate in alveolar socket
https://doi.org/10.23805/jo.2015.07.01.02
Accepted: 31 May 2017
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Aim The objective of this study was to assess the capacity of beta-tricalcium phosphate to facilitate bone formation in the socket and prevent post-extraction alveolar resorption.
Materials and methods After premolar extraction in 16 patients, the sockets were filled with beta-tricalcium phosphate. Six months later, during the implant placement surgery, a trephine was used to harvest the bone samples which were processed for histological and histomorphometrical analyses. Data were gathered on patient, clinical, histological and histomorphometric variables at the extraction and implant placement sessions, using data collection forms and pathological reports.
Results Clinical outcomes were satisfactory, the biomaterial was radio-opaque on X-ray. Histological study showed: partial filling with alveolar bone of appropriate maturation and mineralization for the healing time, osteoblastic activity and bone lacunae containing osteocytes. The biomaterial was not completely resorbed at six months.
Conclusion Beta-tricalcium phosphate is a material capable of achieving preservation of the alveolar bone when it is positioned in the immediate post-extraction socket followed by suture; it also helps the formation of new bone in the socket. Further studies are needed comparing this technique with other available biomaterials, with growth factors and with sites where no alveolar preservation techniques are performed.
Allegrini S Jr, Koening B Jr, Allegrini MR, Yoshimoto M, Gedrange T, Fanghaenel J et al. Alveolar ridge sockets preservation with bone grafting-review. Ann Acad Med Stetin 2008;54:70-81.
Khan Y, Yaszemski MJ, Mikos AG, Laurencin CT. Tissue engineering of bone: material and matrix considerations. J Bone Joint Surg Am 2008;90(Suppl 1):36-42.
Tripplet RG, Schow SR, Laskin DM. Oral and maxillofacial surgery advances in implant dentistry. Int J Oral Maxillofac Implants 2000;15:47-55.
Zijderveld SA, Zerbo IR, van der Bergh JPA, Schulten EAJM, ten Bruggenkate CM. Maxillary sinus floor augmentation using a beta-tricalcium phosphate (Cerasorb) alone compared to autogenous bone grafts. Int J Oral Maxillofac Implants 2005;20:432-40.
Darby I, Chen S, De Poi R. Ridge preservation: what is it and when should it be considered. Aust Dent J 2008;53:11-21.
Giannoudis PV, Dinopoulos H, Tsiridis E. Bone substitutes: an update. Injury 2005;36 Suppl 3:S20-7.
Deppe H, Horch H, Neff A. Conventional versus CO2 laser-assisted treatment of peri-implant defects with the concomitant use of pure-phase β-tricalcium phosphate: a 5-year clinical report. Int J Oral Maxillofac Implants 2007;22:79-86.
Franch J, DÃaz-Bertrana C, Lafuente P, Fontecha P, Durall I. Beta-tricalcium phosphate as a synthetic cancellous bone graft in veterinary orthopaedics. A retrospective study of 13 clinical cases. Vet Comp Orthop Traumatol 2006;19:196-204.
Gan Y, Dai K, Zhang P, Tang T, Zhu Z, Lu J. The clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusion. Biomaterials 2008;29:3973-82.
Liu G, Zhao L, Cui L, Liu W, Cao Y. Tissue-engineered bone formation using human bone marrow stromal cells and novel beta-tricalcium phosphate. Biomed Mater 2007;2:78-86.
Allabouch A, Colat-Parros J, Salmon R, Naim S, Meunier JM. Biocompatibility of some materials used in dental implantology: histological study. Colloids Surf B Biointerfaces 1993;1:323-9.
Aybar B, Bilir A, Akçakaya H, Ceyhan T. Effects of tricalcium phosphate bone graft materials on primary cultures of osteoblast cells in vitro. Clin Oral Impl Res 2004;15:119-25.
Byun H, Wang H. Sandwich bone augmentation using recombinant human platelet-derived growth factor and beta-tricalcium phosphate alloplast: case report. Int J Periodontics Restorative Dent 2008;28:83-7.
Alam S, Ueki K, Marukawa K, Ohara T, Hase T, Takazakura D et al. Expression of bone morphogenetic protein 2 and fibroblast growth factor 2 during bone regeneration using different implant materials as onlay bone graft in rabbit mandibles. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:16-26.
Boix D, Weiss P, Gauthier O, Guicheux J, Bouler JM, Pilet P et al. Injectable bone substitute to preserve alveolar ridge resorption after tooth extraction: a study in dog. J Mater Sci Mater Med 2006;17:1145-52.
Fiorellini JP, Kim DM, Nakajima Y, Weber HP. Osseointegration of titanium implants following guided bone regeneration using expanded polytetrafluoroethylene membrane and various bone fillers. Int J Periodontics Restorative Dent 2007;27:287-94.
Masago H, Shibuya Y, Munemoto S, Takeuchi J, Umeda M, Komori T et al. Alveolar ridge augmentation using various bone substitutes--a web form of titanium fibers promotes rapid bone development. Kobe J Med Sci 2007;53:257-63.
Suba Z, Takács D, Gyulai-Gaäl S, Kovács K. Facilitation of beta-tricalcium phosphate-induced alveolar bone regeneration by platelet-rich plasma in beagle dogs: a histologic and histomorphometric study. Int J Oral Maxillofac Implants 2004;19:832-8.
Horch HH, Sader R, Pautke C, Neff A, Deppe H, Kolk A. Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the reconstructive surgery of the jaws. Int J Oral Maxillofac Surg 2006;35:708-13.
Suba Z, Takács D, Matusovits D, Barabás J, Fazekas A, Szabó G. Maxillary sinus floor grafting with beta-tricalcium phosphate in humans: density and microarchitecture of the newly formed bone. Clin Oral Impl Res 2006;17:102-8.
Szabó G, Huys L, Coulthard P, Maiorana C, Garagiola U, Barabas J et al. A prospective multicenter randomized clinical trial of autogenous bone versus beta-tricalcium phosphate graft alone for bilateral sinus elevation: histologic and histomorphometric evaluation. Int J Oral Maxillofac Implants 2005;20:371-81.
Ormianer Z, Palti A, Shifman A. Survival of immediately loaded dental implants in deficient alveolar bone sites augmented with beta-tricalcium phosphate. Implant Dent 2006;15:395-403.
Brkovic BM, Prasad HS, Konandreas G, Milan R, Antunovic D, Sándor GK et al. Simple preservation of a maxillary extraction socket using beta-tricalcium phosphate with type I collagen: preliminary clinical and histomorphometric observations. J Can Dent Assoc 2008;74:523-8.
Horowitz RA, Mazor Z, Miller RJ, Krauser J, Prasad HS, Rohrer MD. Clinical evaluation of alveolar ridge preservation with a beta-tricalcium phosphate socket graft. Compend Contin Educ Dent 2009;30:588-90, 592, 594 passim; quiz 604, 606
Brkovic BM, Prasad HS, Rohrer MD, Konandreas G, Agrogiannis G, Antunovic D, Sándor GK. Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation. Clin Oral Investig 2012;16:581-90.
von Doernberg MC, von Rechenberg B, Bohner M, Grünenfelder S, van Lenthe GH, Müller R et al. In vivo behavior of calcium phosphate scaffolds with four different pore sizes. Biomaterials 2006;27:5186-98.
Walsh WR, Vizesi F, Michael D, Auld J, Langdown A, Oliver R et al. Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model. Biomaterials 2008;29:266-71.
Wiltfang J, Merten HA, Schlegel KA, Schultze-Mosgau S, Kloss FR, Rupprecht S et al. Degradation characteristics of alpha and beta tri-calcium-phosphate (TCP) in minipigs. J Biomed Mater Res 2002;63:115-21.
Zerbo IR, Bronckers AL, de Lange G, Burger EH. Localisation of osteogenic and osteoclastic cells in porous beta-tricalcium phosphate particles used for human maxillary sinus floor elevation. Biomaterials 2005;26:1445-51.
Martinez A, Franco J, Saiz E, Guitian F. Maxillary sinus floor augmentation on humans: Packing simulations and 8 months histomorphometric comparative study of anorganic bone matrix and β-tricalcium phosphate particles as grafting materials. Mater Sci Eng C Mater Biol Appl 201015;30:763-9.
Iasella JM, Greenwell H, Miller RL, Hill M, Drisko C, Bohra AA et al. Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol 2003;74:990-9.
De Coster P, Browaeys H, De Bruyn H. Healing of extraction sockets filled with BoneCeramic® prior to implant placement: preliminary histological findings. Clin Implant Dent Relat Res 2011;13:34-45.
Zerbo IR, Zijderveld SA, de Boer A, Bronckers AL, de Lange G, ten Bruggenkate CM et al. Histomorphometry of human sinus floor augmentation using a porous beta-tricalcium phosphate: a prospective study. Clin Oral Implants Res 2004;15:724-32.
Horowitz RA, Mazor Z, Foitzik C, Prasad H, Rohrer M, Palti A. b-tricalcium phosphate as bone substitute material: properties and clinical applications. J Osseointegr 2010;2(2):61-68.
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