Antibacterial properties and side effects of chlorhexidine-based mouthwashes. A prospective, randomized clinical study

  • E. Polizzi
  • G. Tetè | tetegiulia92@gmail.com DDS, Specialization School in Oral Surgery, Vita-Salute San Raffaele University, Milan, Italy, Italy.
  • F. Bova
  • G. Pantaleo
  • G. Gastaldi
  • P. Capparè
  • E. Gherlone

Abstract

Aim Chlorhexidine (CHX) is commonly used in clinical applications, including plaque control and gingivitis treatment. The im of this study was to evaluate the clinical properties, in terms of plaque control, bleeding and discoloration levels, of six CHX mouthwashes that differ in the following characteristics: CHX concentration, presence/absence of alcohol and presence/absence of an anti-discoloration system (ADS).

Materials and methods A single-center, prospective, double-blind randomized clinical trial was carried out on 78 consecutive patients. Six mouthwashes (CHX 0.12% alcohol free; CHX 0.20% alcohol free; CHX 0.12% alcohol free with ADS; CHX 0.20% alcohol free with ADS; CHX 0.12% with alcohol; CHX 0.20% with alcohol) were tested. Plaque Index (PI) and Bleedind Index (BI) were recorded, along with tooth staining (spectrophotometry) at T0 (beginning), at T1 (after 7 days), at T2 (after 14 days), and T3 (after 21 days). Data obtained were subjected to statistical analysis.

Results All CHX mouthwashes significantly reduced PI (p<0.0001), while only alcohol free CHX 0.20% significantly reduced BI (p<0.0001). Only the CHX 0.12% with alcohol and CHX 0.20% with alcohol mouthwashes showed a significant presence of extrinsic tooth staining (p<0.05).

Conclusions Within the limitations of the present study, the alcohol-free mouthwash CHX 0.20% allows a good control of the clinical indices, in particular the bleeding index. 

Downloads

Download data is not yet available.
Published
2019-10-28
Section
Articles
Keywords
Chlorhexidine, Mouthwashes, Oral cancer, Tooth staining
Statistics
Abstract views: 29

pdf: 22
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Polizzi, E., Tetè, G., Bova, F., Pantaleo, G., Gastaldi, G., Capparè, P., & Gherlone, E. (2019). Antibacterial properties and side effects of chlorhexidine-based mouthwashes. A prospective, randomized clinical study. Journal of Osseointegration, 2-7. https://doi.org/10.23805/JO.2019.12.01.20