Oxidant And Antioxidant Status Of Peri-Implant Crevicular Fluid In Patients With Sandblasted Acid-Etched And Anodized Dental Implants: A Prospective Clinical Study
Oxidant and antioxidant status among patients with diverse surface treated dental implants
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Accepted: 8 September 2025
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Background
Exploring oxidant and antioxidant profile around different surface treated dental implants is essential to improve the performance of implants. The purpose of this research was to assess total antioxidant capacity (TAOC), total oxidant status (TOS) and oxidative stress index (OSI) in peri-implant crevicular fluid among patients with sandblasted acid-etched and anodized dental implants.
Materials and Methods
In this prospective clinical study, 78 patients who had undergone implant placement for missing single posterior tooth in mandible using sandblasted acid-etched and anodized dental implants during August 2019 - December 2019 were enrolled and categorized into Group 1: SLA (n=27), Group 2: SLActive (n=26), Group 3: TiUnite (n=25) based on the surface modification of implants. Peri-implant crevicular fluid (PICF) was collected at baseline (3 months after placement, before functional loading) and again at 1 year from implant placement to assess TOS, TAOC, OSI using calorimetric assays.. Statistical analysis was performed using one-way ANOVA for intergroup comparison, followed by Tukey’s HSD post hoc for pairwise comparison. For intragroup comparison, paired t test was used.
Results
TOS and OSI in group 3 implants were higher than groups 1 and 2 (p≤0.05). TAOC in group 3 implants was lower than groups 1 and 2 (p≤0.05). On pairwise comparison, there was a significant difference between the groups at baseline (p≤0.05) and 1-year follow up (p≤0.05). Intragroup comparison showed statistically significant difference in terms of TOS, TAOC and OSI from baseline in all the three groups (p≤0.05).
Conclusion
Higher total oxidative capacity and oxidative stress index as well as lower antioxidative activity were observed in peri-implant crevicular fluid around TiUnite dental implants.
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